Background
A global pharmaceutical company required a robust computational infrastructure to support CryoSPARC, a cutting-edge application used for cryo-electron microscopy (cryo-EM) image processing. This tool is critical for identifying molecular structures that drive drug discovery. To enhance scalability, performance, and compliance the company had chosen an AWS-hosted solution, leveraging Court Square Group’s expertise in Life Sciences IT management.
Solution Implementation
AWS Cloud Hosting:
- Scalable Compute: Deployed CryoSPARC on AWS Elastic Compute Cloud (EC2) instances optimized for high-performance workloads (e.g., GPU-accelerated computing).
- Storage: Leveraged Amazon S3 for storing large volumes of cryo-EM data and Elastic File System (EFS) for rapid, secure file sharing.
Managed Services by Court Square Group:
- Compliance Framework: Implemented a validated infrastructure adhering to FDA 21 CFR Part 11 and GxP guidelines.
- Monitoring and Support: Continuous system monitoring and proactive issue resolution through Court Square’s Managed Services team.
- Data Security: Incorporated encryption protocols and regular security audits to protect sensitive research data.
CryoSPARC Optimization:
- Fine-tuned the application’s integration with AWS GPU instances to maximize performance during 3D reconstruction and structural analysis
Outcomes
- Performance Gains: Reduced image processing time by 50%, accelerating drug discovery workflows.
- Scalability: Enabled Global Pharmaceutical Company to scale computational resources dynamically, meeting peak research demands.
- Regulatory Compliance: Maintained compliance with rigorous life sciences standards, ensuring data integrity and audit readiness.
- Cost Efficiency: AWS’s pay-as-you-go model and Court Square’s resource optimization strategies reduced operational costs by 20%.
Conclusion
The combination of AWS’s scalable infrastructure and Court Square Group’s specialized management allowed the global pharmaceutical company to streamline CryoSPARC operations while maintaining compliance and optimizing costs. This partnership highlights the potential for cloud-hosted applications in advancing scientific innovation in the pharmaceutical sector.